Pharmacogenetics: medicines according to your genetics

Pharmacogenetics: medicines according to your genetic

Precision medicine and lifestyle: an integrative approach

Pharmacogenetics: medicines according to your genetics is an innovative approach that puts personalised health within reach of every individual. In precision and lifestyle medicine, the aim is not to exclude medicines, but to integrate them into a holistic approach that, through healthy habits, allows in many cases to reduce their use or even make them unnecessary. Through nutrition, physical activity, stress management and rest, among others, many patients can achieve optimal health without relying solely on drugs. However, when the use of drugs is necessary, pharmacogenetics can personalise their doses and avoid side effects by tailoring them to the genetics of each patient.

How does pharmacogenetic influence treatments?

Pharmacogenetic studies how genetic variations affect an individual’s response to medicines. Although we all share more than 99.9% of our DNA, these small variations can determine whether a drug is effective, whether its dosage needs to be adjusted or whether it may produce adverse effects. Pharmacogenetics: medicines according to your genetics becomes a key concept in understanding how medical treatments can be adjusted to maximise their benefits for each individual patient.

Pharmacogenetic

Metaboliser types: a key to pharmacogenetic

One of the greatest advantages of pharmacogenetic is that it allows us to know what type of metaboliser we are. This classification helps us to understand why some people respond well to certain drugs, while others experience side effects or do not get the relief they expect. The types of metabolisers, according to pharmacogenetic, are:

1. Poor metabolisers: they process medicines slowly, which can lead to accumulation in the body and increase the risk of toxicity.
2. Intermediate metabolisers: have slightly slower enzyme activity, which may require adjustment of the drug dose.
3. Normal metabolisers: process drugs at an average rate and usually obtain the appropriate therapeutic effect without adjustment.
4. Ultra-rapid metabolisers: these eliminate medicines too quickly, which can reduce their effectiveness and, in some cases, require an increase in dosage.

Example of a pharmacogenetic test

Pharmacogenetic: medicines according to your genetic allows doctors to adjust medication and doses precisely according to the type of metaboliser, minimising risks and maximising benefits.

Pharmacogenetic

One-size-fits-all medicines: the challenge of the same dose for everyone

Traditionally, medicines have been prescribed on a ‘one-size-fits-all’ model. This standard approach ignores genetic differences in individuals, which carries two major risks:

1. Overdosage: In slow metabolisers, the drug may accumulate, increasing the risk of serious side effects.
2. Lack of therapeutic effect: in rapid metabolisers, the drug may not reach the required concentration in the body, reducing its efficacy.

With pharmacogenetics: medicines according to your genetics, it is possible to personalise treatments to avoid these problems and adjust medicines according to each patient’s unique biology.

Genes influencing pharmacogenetic

The response to certain drugs is influenced by specific genes that affect their metabolisation. Some of the most important genes in pharmacogenetics include:

• CYP2D6 y CYP2C19: affect the response to antidepressants, antipsychotics and analgesics. Thanks to pharmacogenetic, the dosage can be adjusted by choosing an alternative drug.
• SLCO1B1: determines the transport of statins, used to lower cholesterol. Some people with variants in this gene are at increased risk of muscle side effects.

Pharmacogenetic: medicines according to your genetic optimises the selection of medicines and avoids adverse reactions thanks to the knowledge of the patient’s genetic profile.

Personalised medication: tailoring treatment to your genetics

In contrast to the ‘one-size-fits-all’ model, pharmacogenetic proposes a personalised medication approach that improves the safety and efficacy of treatments:

1. Increased safety: side effects are minimised by tailoring medication to the genetics of each patient, avoiding hospitalisations.
2. Optimised efficacy: medicines are adapted to the individual’s metabolism, improving their results.
3. Reduced testing and errors: pharmacogenetic saves time and resources by selecting the most appropriate treatments from the outset.

Conclusion: towards truly personalised medicine

Pharmacogenetic: medicines according to your genetic represents a fundamental advance in personalised medicine. This approach allows treatments to be tailored to individual needs, reducing risks and improving outcomes. With the integration of pharmacogenetic, medicine is moving towards tailor-made solutions, adapted to the genetic profile and lifestyle of each patient.

Would you like to know how pharmacogenetic can optimise your treatment? At Bhital.com, we are here to help you discover the benefits of precision medicine and healthy lifestyle. Book your appointment or send us a WhatsAppal 669 979 939 and transform your health with a tailored approach.