Rejuvenate and live healthy

Rejuvenate and live healthy

In this article I aim to provide a comprehensive and accessible overview of the scientific and preventive aspects of ageing. Stressing the importance of a holistic and active approach to the ageing process in order to rejuvenate and live healthily.

Molecular mechanisms of ageing

A seminal study, ‘The Hallmarks of Aging’, details the molecular mechanisms associated with ageing, ranging from molecular biology to genetics. Principal investigators include Carlos López-Otín, Maria A. Blasco, Linda Partridge, Manuel Serrano and Guido Kroemer (López OtÍn et al., Hallmarks of aging: An expanding universe, Cell (2023), https://doi.org/10.1016/ j.cell.2022.11.001).

The 12 molecular mechanisms of ageing

1. Genomic instability: DNA damage due to external and internal factors that compromise genetic integrity.
2. Telomerase attrition: telomeres, which protect the ends of chromosomes, shorten with each cell division, limiting the ability of cells to divide.
3. Epigenetic alterations: changes in the regulation of gene expression without altering the genetic code that affect cell function.
4. Loss of proteostasis: decreased ability of cells to maintain functional proteins, leading to accumulation of misfolded proteins and protein aggregates.
5. Disabled macroautophagy: inefficient degradation and recycling of damaged cellular components.
6. Dysregulation of nutrient sensors: alterations in signalling pathways that sense and respond to nutrients, affecting metabolism and cell growth.
7. Mitochondrial dysfunction: loss of efficiency and damage to the mitochondria, the powerhouses of the cell, which decreases energy production and increases oxidative stress.

Rejuvenate and live healthily

8. Cellular senescence: a state in which cells stop dividing and start secreting inflammatory and degradative factors.

9. Stem cell depletion: decrease in the ability of stem cells to regenerate tissues, contributing to the deterioration of tissues and organs.

10. Impaired intercellular communication: changes in communication between cells that can lead to chronic inflammation and impaired tissue function.

11. Chronic inflammation: persistent inflammation that can contribute to a number of chronic diseases and ageing.

12. Dysbiosis: changes in the composition and function of the gut microbiota that affect systemic health.

Areas most affected by ageing

Seven main areas are affected by ageing:

1. Cardiovascular system
2. Glucose regulation
3. Musculoskeletal system
4. Brain function
5. Endocrine function
6. Immune system
7. Oxidative stress management system

The decade of healthy ageing

The WHO has designated the period between 2020 and 2030 as the decade of Healthy Ageing, with the aim of improving the living conditions of older people. This effort is based on the concept of active ageing and aims to increase healthy life expectancy.

Rejuvenate and live healthily

Conclusions

hanks to the knowledge of why we age, we can act on these aspects for prevention. Through a holistic approach to individuals, it is possible to develop a personalised care plan that includes nutrition, physical and mental activity, as well as supplements, among other elements of care.

Have a healthy Birthday!

If you want to celebrate your birthday in good health and without limitations, now is the time. Request a free orientation appointment with Dra. Carmen Romero, specialist in longevity and anti-aging, by sending a WhatsApp to 699 979 939. Take advantage of this opportunity to improve your quality of life and age in an active and healthy way. Your future starts today!

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